Cilostazol is a quinolinone derivative used for treatment of intermittent claudication and peripheral vascular disease. Learn about side effects, drug interactions, dosages, warnings, and more. Cilostazol is used to reduce the symptoms of intermittent claudication (pain in the legs that worsens when walking and improves when resting that is caused by narrowing of the blood vessels that supply blood to the legs). DESCRIPTION. PLETAL (cilostazol) is a quinolinone derivative that inhibits cellular phosphodiesterase (more specific for phosphodiesterase III). The empirical formula of cilostazol is C 20 H 27 N 5 O 2, and its molecular weight is 369.46. A dosagem recomendada é de 50 mg ou 100 mg duas vezes ao dia, conforme orientação médica. Deve-se considerar a dose de 50 mg duas vezes ao dia quando houver coadministração com inibidores do CYP3A4, como cetoconazol, itraconazol, eritromicina e diltiazem, e com inibidores do CYP2C19, como omeprazol. Cilostazol is a vasodilator that works by relaxing the muscles in your blood vessels to help them dilate (widen). Cilostazol dilates arteries that supply blood to your legs. NDA 20-863/S-021 Page 2 PLETAL (PLAY-tal) (cilostazol) (sil-OS-tah-zol) Tablets CONTRAINDICATION Cilostazol and several of its metabolites are inhibitors of phosphodiesterase III. Cilostazol Tablets are indicated for the reduction of symptoms of intermittent claudication, as demonstrated by an increased walking distance. Find patient medical information for Cilostazol Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Older adults may be more sensitive to the side effects of cilostazol. This medicine controls symptoms of intermittent claudication, but it doesn't cure the condition. carmelose cálcica, sicovit laca indigotina, dióxido de silício coloidal, estearato de ma e celulose gnésio microcristalina.